Effects of ginsenoside-Rg1 on levels of t-PA and PAI-1
- VernacularTitle:三七皂苷Rg1对t-PA和PAI-1水平的影响
- Author:
Heqin ZHAN
;
Pingfa LI
;
Jinnan YANG
;
Jinghua MO
;
Zhiqiang SHEN
- Publication Type:Journal Article
- Keywords:
ginsenoside-Rg1;
antithrombosis;
tissue type plasminogen activator;
plasminogen activator inhibitor type 1
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects and its mechanisms of ginsenoside-Rg1 on level of t-PA and PAI-1.Methods Type 1 plasminogen activator inhibitor(PAI-1) and tissue type plasminogen activator(t-PA) activity in plasma were assayed using chromogenic substrate.Results The results showed that ginsenoside-Rg1 in vitro or in vivo significantly inhibited PAI-1activity,while increased t-PA activity.These effects were concentration-dependent.Intravenous Panax notoginsenoside Rg1 at 30,60,120 and 240 mg?kg~(-1) markedly suppressed PAI-1 level in plasma as well as platelet-released substances stimulated by thrombin,while increased plasma t-PA activity.And release level of PAI-1 owing to blood platelet was greatly decreased by ginsenoside-Rg1.Conclusion Ginsenoside-Rg1 showed potent antithrombosis due to the inhibition of PAI-1 and increase of t-PA.It might also be a advantagous mechanism to its antithrombsis.
