Effects of atorvastatin on lipid profile modification and brachial artery endothelial function in hypercholesterolemic patients
- VernacularTitle:阿托伐他汀对高胆固醇血症患者的血脂和血管内皮功能的影响
- Author:
Hong XUE
- Publication Type:Journal Article
- Keywords:
atorvastatin;
serum lipid;
endothelial function
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of atorvastatin on lipid profile modification and brachial artery endothelial function in hypercholestrolemic patients.Methods Totally 128 hypercholestrolemic patients were randomized to receive atorvastatin(10 mg/d,qn,n=64) or simvastatin as control(20 mg/d,qn,n=64).Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4-and 8-week treatment respectively.The changes of brachial artery internal diameter under reactive hyperemia situation or after taking nitroglycerin(500 ?g) were respectively evaluated by B-mode ultrasonography.Results The effects of atorvastatin in lowering serum total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) levels were the same as simvastatin.The changes of brachial artery internal diameter under reactive hyperemia situation and after taking nitroglycerin(500 ?g) in hypercholestrolemic patients were significantly increased after treatment.Conclusion Atorvastatin could decrease the serum level of TC,LDL-C and TG and improve the brachial artery endothelial function,and its effects were similar to simvastatin.
