The effect of simvaslalin on serum level of matrix metalloprotease-9 and tissue inhibitors of matrix metalloproteinase-1 in patients with acute coronary syndromes
- VernacularTitle:普伐他汀对急性冠状动脉综合征患者血清组织抑制因子-1及基质金属蛋白酶-9水平的影响
- Author:
Jie WANG
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Simvastatin;
Matris metalloproteinases;
Tissue inhibitors of matris metalloproteinase
- From:Chinese Journal of Primary Medicine and Pharmacy
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of slmvastatin of serun levels of matrix metalloprotease-9(MMP-9) and tissue inhibitors of matris metalloproteinase-1(TIMP-1) in patients with acute coronary syndromes(ACS).Methods There were 30 patients with stable angina pectoris(SAP) and 30 patients with ACS.28 cases of age matched healthy individuals were selected as a control.The serum level of MMP-9 and TIMP-1 were detected by ELISA before and after treatment.Results There was a significant diferencein serum level of MMP-9 and TIMP-1 among SAP group,ACS group and control group.The serum level of MMP-9 and TIMP-1 were diferent between simanastatin treatment before and after 4 weeks treatment.Conclusion ACS may be related to the increased serum level of MMP-9 and the decreased serum level of TIMP-1.Simavastatin can decrease serum level of MMP-9 and increase serum level of TIMP-1,and it may be have a beneficial effect on clinical treatment.
