Correlation and significance of tissue factor and p53 protein expression in colorectal carcinoma
- VernacularTitle:结直肠癌中组织因子和p53蛋白表达的相关性及其意义
- Author:
Tao WU
;
Yuanlian WAN
;
Yucun LIU
- Publication Type:Journal Article
- Keywords:
thromboplastin;
protein p53;
colorectal neoplasms;
lymphatic metastasis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of tissue factor (TF) and p53 protein expression in colorectal carcinoma. Methods The expression of TF and p53 protein was studied by immunohistochemistry in 43 cases of primary colorectal carcinoma. Results TF expression was positive in 44.2% (19/43) of cases, and p53 protein expression was positive in 48.8% (21/43) of cases. The lymph node metastatic rate was 78.9% (15/19) in patients with positive expression of TF, and 85.7% (18/21) in patients with positive p53 protein expression. Both TF and p53 protein expressions showed significant correlation with lymph node metastasis (?~2=8.96 and 14.88, P
