Studies on physiology of sleeping of swine model with obstructive sleep apnea syndrome
- VernacularTitle:阻塞性睡眠呼吸暂停综合征模型猪睡眠生理研究
- Author:
Liming ZHAO
;
Bing LI
;
Haiqing WANG
- Publication Type:Journal Article
- Keywords:
sleep apnea, obstructive;
animal model;
hypnic physiology;
pathology of pharyngeal tissue
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the physiology of sleeping in a swine model with obstructive sleep apnea syndrome (OSAS) reproduced by high altitude and hypoxia. Methods Twelve male minipigs were randomly assigned to 2 groups, named A and B. The pigs of Group A were placed in Room 1, which was a double-room altitude chamber, and the pressure in it was adjusted to 53.9 kPa with an oxygen concentration of 10.0%~11.2%. The pigs of Group B were kept in Room 2 with altitude of sea level and oxygen concentration of 21%. All the animals were kept in their respective rooms for 6 hours per day and for 22 consecutive days. On the 23rd day sleeping was monitored, at the same time the movements of chest and abdomen, respiratory airflow, heart rate, and pulse oxygen saturation (SpO_2) were recorded. Apnea/Hypopnea Index (AHI), Hypopnea Index (HI), and average SpO_2 were derived from analysis of the data of sleeping monitoring. Pigs were sacrificed after the experiment, and pharyngeal tissue was harvested for pathological examination. Results The AHI (16.1?8.3 vs 2.3?1.6), HI (4.3?3.1 vs 1.3?1.0), SpO_2 (86.7?3.6 vs 94.5?1.8) of pigs of group A showed were have significant differences compared with that of the control (P
