The change in somatosensory evoked potential caused by infusing adriamycin magnetic gelatin microspheres into subarachnoid space of rabbits
- VernacularTitle:蛛网膜下腔注射阿霉素磁性明胶微球对家兔体感诱发电位的影响
- Author:
Yong WANG
;
Yonghai SUN
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
gelatin;
doxorubicin;
microspheres;
evoked potential, somatosensory
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes in somatosensory evoked potential caused by injection of adriamycin magnetic gelatin microspheres into subarachnoid space of rabbits. Methods Thirty rabbits were randomly divided into 5 groups: sham operation group (group S), gelatin microspheres 5mg (group C1), 15mg of gelatin microsphere (group C2) controlled groups, and adriamycin microspheres 5mg (group A1) and 15mg (group A2) groups. Under the effect of magnet, microspheres were injected into the subarachnoid space of rabbits. The pain threshold of electronic stimulation, motor function of rabbits′ hinder limbs and somatosensory evoked potential (SEP) were observed continuously. Results Obvious rise of pain threshold was found in group A2 (P
