Influence of propofol on spinal cord transected rat vascular reactivity
- VernacularTitle:异丙酚对脊髓损伤后大鼠血管反应性的影响
- Author:
Xueyin SHI
;
Zui ZOU
;
Jianhua XIA
- Publication Type:Journal Article
- Keywords:
spinal cord injuries;
autonomic dysreflexia;
receptors, adrenergic, alpha;
vascular reactivity;
propofol
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the reactivity of spinal cord transection (SCT) rat abdominal aorta to ?-AR agonists and the infuence of propofol on vascular reactivity, so as to explore the mechanism of autunomic dysreflxia. Methods The rats were divided into sham-operated group and SCT group. 4 weeks after transection of the fourth thoracic spinal cord, the rats were killed, then abdominal aorta rings were adopted to assay their sensitivity to noradrenaline, phenylephrine, clonidine and propofol in isolated organ perfusion system. Results Compared with the rats in sham-operated group, the abdominal aorta reactivity of SCT rats to noradrenaline and clonidine was significantly higher (P
