Valsartan reduces the recurrence of atrial fibrillation and delays atrial structural remodeling in patients with paroxysmal atrial fibrillation
- VernacularTitle:缬沙坦减少心房颤动复发及延缓心房结构重构的临床观察
- Author:
Xiaobo GAI
;
Mingfang HUANG
;
Jianping HOU
- Publication Type:Journal Article
- Keywords:
atrial fibrillation;
amiodarone;
valsartan;
atrial structural remodeling
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the curative effect of valsartan associated with low-dose amiodarone on the recurrence of atrial fibrillation (AF), the left atrial diameter (LAD), P wave dispersion (Pd) and the maximum P wave duration (Pmax) in patients with paroxysmal AF. Methods 76 patients with paroxysmal atrial fibrillation (PAF) were randomized to valsartan (test group) and placebo (placebo group), both associated with low-dose amiodarone, and were followed up for 18 months. The patients were asked to report any episode of symptomatic atrial fibrillation and to perform an ECG as early as possible. AF load, Pmax, Pd and LAD were measured before and at the 6th, 12th, and 18th months after the treatment. Results At least one ECG-documented episode of AF was reported in 16% of the patients in test group and in 41% in placebo group, the difference was significant(P
