Changes of ghrelin and leptin levels in patients with obstructive sleep apnea syndrome before and after treatment of continuous positive airways pressure
- VernacularTitle:持续气道内正压通气治疗阻塞性睡眠呼吸暂停综合征前后血清瘦素及胃饥饿素的变化
- Author:
Shi WANG
;
Gang LU
;
Lei CHEN
- Publication Type:Journal Article
- Keywords:
Ghrelin;
Leptin;
OSAS;
CPAP
- From:
Chinese Journal of Practical Internal Medicine
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
30,BMI≥25 kg?m -2 ),who were admitted to the hospital from Apr.2004 to Sep.2005,were induded in the study.They underwent CPAP.The PSG and leptin,ghrelin,true insulin,fasting blood glucose are measured before the treatment,and one week and six months after the treatment.Results After one week,there was a little decrease of leptin and ghrelin,and no change in true insulin and fasting blood glucose.After six months,only 16 patients improved a lot in AHI and hypoxemia.There was significant decrase of leptin and ghrelin and also a change of true insulin.Conclusion These data indicate that the elevated leptin and ghrelin levels are not determined by obesity alone,since they decrease during CPAP therapy.The glucose metabolic disturbance and insulin resistance in OSAS are improved after 6 months of CPAP therapy.Therefore,we can think that OSAS patients have metabolic disturbance of leptin and ghrelin,which is one of factors of obesity.
