Evaluation of nasal continuous positive airway pressure on prethrombotic state in obstructive sleep apnea syndrome
- VernacularTitle:经鼻无创正压通气治疗阻塞性睡眠呼吸暂停综合征血栓前状态效果评价
- Author:
Lei PAN
;
Yong WANG
;
Yue SUN
- Publication Type:Journal Article
- Keywords:
OSAS;
Prethrombotic state;
Nasal continuous positive airway pressure
- From:
Chinese Journal of Practical Internal Medicine
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the effects of nasal continuous positive airway pressure(nCPAP)therapy on patients with OSAS in prethrombotic state.Methods One group of 30 patients with OSAS who were diagnosed from Sep.2003 to Sep.2005,one healthy control group of 30 cases.Blood samples were taken from people in the supine position in the morning immediately after overnight polysomnography and nCPAP theraphy(only in OSAS group).Results Compared with the normal controls,the level of the molecular marker GMP-140 increased in the blood of patients with OSAS,the levels of APTT,AT-Ⅲ decreased,and the level of t-PA decreased as well.The level of PAI increased.Compared with the healthy controls,datum indicated statistical differences between the two groups.Datum of the patients with OSAS were improved after nCPAP therapy:AHI decreased from 63.21?23.23 to 0.56?0.84;the nocturnal lowest of SaO_2 increased from 0.68?0.07 to 0.90?0.02;GMP-140 and PAI decreased to (17.07?7.97)% and (95.83?5.91)% respectively;AT-Ⅲ and t-PA increased to(95.20?6.67)% and (5.45?1.61)?g respectively.Conclusion Prethrombotic state is present in patients with OSAS.nCPAP therapy can decrease OSAS-related thrombotic complications.
