MMP-1 and TIMP-1 expression in pubocervical fascia from patients with stress urinary incontinence
- VernacularTitle:MMP-1及TIMP-1在压力性尿失禁患者耻骨宫颈筋膜中的表达
- Author:
Yanzhou WANG
;
Zhiqing LIANG
;
Huicheng XU
;
Dan WANG
- Publication Type:Journal Article
- Keywords:
urinary incontinence,stress;
collagen;
matrix metalloproteinases;
tissue inhibitor of metalloproteinase
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate collagen metabolism in stress urinary incontinence(SUI) so as to determine the alteration that contributes to SUI.Methods Biopsy specimens of vaginal wall tissue from 24 women with stress urinary incontinence were collected,with matched specimens from 24 female patients without SUI.Immunohistochenical technique were applied to detect the expression of MMP-1 and TIMP-1.Results SUI group demonstrated a significant increase in MMP-1 expression and a decrease in TIMP-1 expression,with significant difference with control group.Conclusion Patients with SUI were in the predominant status of collagen breakdown,which may contribute to the pathogenesis of SUI.
