ROS level and ASK1 protein expression in myocardium during chronic pressure overload in rat left ventricle
- VernacularTitle:压力超负荷下大鼠左心室活性氧水平及凋亡信号调节激酶蛋白表达
- Author:
Min QIU
;
Kanghua MA
- Publication Type:Journal Article
- Keywords:
hypertension;
myocardial hypertrophy;
reactive oxygen species;
apoptosis signal regulating(kinase 1)
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of apoptosis signal regulating kinase 1(ASK1) protein expression in hypertrophic myocardium in rat models of hypertension.Methods The rat model of hypertension was established by abdominal aortic constriction.Six weeks later,the reactive oxygen species(ROS) level and ASK1 protein expression in myocardium of left ventricle were detected respectively by color matching and Western blotting.Results The left ventricular mass index,ROS level and ASK1 protein expression all increased significantly in hypertensive rats as compared with those underwent sham operation.Conclusion Under chronic pressure overload,the activated ASK1 with the increasing ROS may play an important role in signal transduction pathway of myocardial hypertrophy.
