Effect of electromagnetic radiation from environment on neural cell adhesion molecular expression in rat hippocampus
- VernacularTitle:环境电磁辐射对大鼠海马神经细胞黏附分子表达的影响
- Author:
Zhaohui DENG
- Publication Type:Journal Article
- Keywords:
electromagnetic radiation;
learning and memory;
neural cell adhesion molecule;
polysialytransferases
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of neural cell adhesion molecule(NCAM) and polysialytransferases(STX) mRNA expression and NCAM protein expression after whole-body exposure to 5 W/cm~2 microwave in rats.Methods A total of 36 Wistar rats were randomly divided into 6 groups receiving 5 W/cm~(2) microwave radiation once a day for 0,1,3,5,10,15 d respectively.NCAM and STX mRNA expression was determined by RT-PCR,and NCAM protein expression by Western blotting.Results The expression of NCAM and STX in rat hippocampus was obviously suppressed by the low dose electromagnetic radiation after 3-day exposure,then recorvered,and the lowest expression level was on exposure day 15.Conclusion Suppression of NCAM and PSA-NCAM is possibly responsible for the impairment of learning and memory ability induced by the electromagnetic radiation.
