The Study of Relationship Between Bcl-2 & p53 Gene Protein Expression and Radiation Sensitivity in Laryngeal Carcinoma
- VernacularTitle:p53和Bcl-2基因蛋白综合表达与喉癌放疗敏感性相关性研究
- Author:
Huaian YANG
;
Koji HOZAWA
;
Tomonori TAKASAKA
- Publication Type:Journal Article
- Keywords:
Laryngeal neoplasms;
Radiation sensitivity;
p53 gene protein;
Bcl-2 gene protein
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to determine the relationship between Bcl-2 and p53 gene protein expression and radiation sensitivity according to the biologic character of laryngeal carcinoma.Methods Using monoclonal antibody for Bcl-2 and p53 gene protein,70 cases of laryngeal carcinoma were stained by immunohistochemical DACO CSA System method.Bcl-2 and p53 gene protein expression were divided into 3 levels:intense,moderate and negative expression.The relationship between expression intensity and radiation sensitivity was tested with Cramer method.Results There was relationship between each gene protein expression and radiation sensitivity.The relationship between cooperative expression and radiation sensitivity was higher than that of individual expression.Conclusion There was significant relationship between Bcl-2 and p53 gene protein coocperative expression and radiation sensitivity.The Bcl-2 and p53 gene protein cooperative expression can be consult criteria in predicting prognosis of radiation therapy of laryngeal carcinoma and instructing clinic therpy.
