The Expression of Secondary Lymphoid Tissue Chemokine(SLC)in Pancreatic Carcinoma and its Clinical Significance
- VernacularTitle:次级淋巴组织因子在胰腺癌组织中的表达及其临床意义
- Author:
Zhong JIA
;
Guanghua FENG
;
Guanhai HE
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasmas;
Angiogenisis;
SLC
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Investigate the expression of secondary lymphoid tissue chemokine (SLC) and its relationship with angiogenisis,pathological feature and prognosis of pancreatic cancer (PC).Methods SLC mRNA expression and microvessel density(MVD) were detected in 22 cases with PC with immunohistochemistry and reverse transcription-polymerase chain reaction(RT-PCR) respectively and compared with its clinical features.Results Mean MVD of PC was 57?12 and enhanced expression of SLC mRNA was detected in 17 cases(77%),The positive rate of SLC mRNA was significantly lower in cases of without metastasis and at early clinical stage(stage Ⅰ+Ⅱ)than that with metastasis and at advanced stage(stage Ⅲ+Ⅳ).MVD was significant higher in SLC mRNA-enhanced PC than in SLC mRNA reduced PC(P
