Clinical Observision of Semimonthly Regimen for Paclitaxel Combined with 5-fluorouracil/leucovorin 48-hour Continuouse Infusion in Treatment of Advanced Breast Cancer Which Resistence CAF Regimen
- VernacularTitle:紫杉醇加醛氢叶酸、5-FU双周疗法治疗CAF方案耐药晚期乳腺癌临床观察
- Author:
Jiujun ZHAO
;
Baozhong HOU
;
Zhenqing LI
- Publication Type:Journal Article
- Keywords:
Paclitaxel;
5-Fluorouracil/Leucovorin 48-hour Continuouse Infusion;
Semimonthly Regimen;
Resistence CAF regimen;
Advanced breast cancer
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical application value of advanced breast cancer which resistence CAF regimen,treated with semimonthly regimen for paclitaxel combined with 5-fluorouracil/leucovorin 48-hour continuouse infusion.Methods 80 paients with CAF-regimen-resistant ABC were treated with paclitaxel combined with 5-fluorouracil/leucovorin continuouse infusion,paclitaxel 95mg/m2,d_1,LV 200mg,d_1,5-fluorouracil 3g/m2,continuouse infusion for 48 hours with infusion pump.every cycle lasted 2 weeks,at least 4 cycles.Results Of 80 patients,there were 9 complete and 26 partial responses,32 cases remained stable and 13 progressive.The overall response rate of 43.8%.The median time to progression was 8 months.The median survival time was 16.7 months,the patients with soft tissue,lung,pleura,bone,liver obtained response rat was 46.7%(21/45),38.5%(5/13),31.3%(5/16),40%(4/10),20%(2/10).Conclusions semimonthly regimen for paclitaxel combined with 5-fluorouracil/leucovorin 48-hour continuouse infusion is effective and acceptable toxicity,it could be considered as one of the standard chemotherapy for advanced breast cancer which resistence CAF regimen.
