STUDY ON THE SENSIBILITY OF LPL-PVUⅡ GENE POLYMORPHISM TO INTERVENTION OF COARSE GRAIN FOOD IN DYSLIPIDEMIA POPULATION
- VernacularTitle:血脂异常人群不同LPL-PvuⅡ基因型对粗杂粮干预的敏感性
- Author:
Xuefen CHEN
;
Chengkai ZHAI
;
Ling JIANG
;
Hui ZUO
- Publication Type:Journal Article
- Keywords:
LPL-PvuⅡ;
blood lipid abnormality;
intervention of coarse food grain
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the different genotypes’ susceptibility to intervention of coarse grain food in dyslipdemia population. Method: 409 middle and old aged residents with blood lipoprotein abnormalities were randomized to 2 groups: the intervention group (230 subjects) and the control group (179 subjects). Everyone of the former group was given a steamed bread of coarse grain food per day and health education once every month; while the control group was only given health education. Intervention period was 6 months. The genotypes of LPL-Pvu Ⅱ of the intervention group were analyzed by PCR-RFLP (restriction fragment length polymorphism) technique. Results: All indices in intervention group except WHR were improved after intervention. BMI, WHR, SBP, DBP, serum TG were significantly lower than control group; while serum HDL-C was significantly higher than control group after intervention. Among all genotype groups, the P+/P+ group was more sensible for the change of serum TG and more significant in the effect of improving blood lipids than the P-/P- group; and the susceptibility of change for TC and HDL-C in serum was least in the P-/P- group. Conclusion: There are good intervention effects of coarse grain food in dyslipdemia population. The susceptibilities to improve blood lipids vary with different geno-types of LPL-Pvu Ⅱ , especially for change of serum TG ,and P+/P+ group was more sensible.
