Nitric oxide and endotnelin-1 concentrations of venous cord blood and its relationship with umbilical arteries blood flow velocity in pregnant women with diabetes mellitus
- VernacularTitle:糖尿病合并妊娠的脐血一氧化氮、内皮素与脐动脉血流阻力关系
- Author:
Min DENG
;
Guihua JIAO
- Publication Type:Journal Article
- Keywords:
Diabetes,gestational;
Nitric oxide;
Endothelin-1;
Umbilical orteries
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of venous cord blood nitric oxide(NO) and endotnelin-1(ET-1) levels and to find out its relationship with umbilical arteries blood flow velocities in the pregnant women with diabetes mellitus.Methods 66 cases of the pregnant women with diabetes mellitus(DM) were selected at random,including 30 diabetes mellitus complicated with pregnancies(DMP) and 36 gestational diabetes mellitus(GDM).36 cases of the normal pregnant(NP) women were selected as the control group.Venous cord blood samples were collected from all the subjects after delivery.Cord blood NO and ET-1 levels were detected by Griess assay and radioimmuno-assay respectively,and umbilical arteries blood flow velocities(S/D) were measured just before delivery.Results Compared with the control group,cord blood NO levels decreased and ET-1 levels increased and S/D increased in the DMP group significantly(P0.05).Conclusion Umbilical blood NO and ET-1 levels are abnormal in DMP,which induces the high resistance of fetal-placental circulation,and finally might cause adverse pregnancy outcomes.
