The research of dexamethasone and higher C-reactive protein on effects of platelets concentrates transfusion
- VernacularTitle:地塞米松及C-反应蛋白增高对血小板输注疗效的影响
- Author:
Xinfa YU
;
Yanhua LIN
;
Hui YANG
;
Wei DONG
- Publication Type:Journal Article
- Keywords:
Thrombocytopenia;
Platelet transfusion;
C-reactive protein Dexamethasone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study dexamethasone and higher C-reactive protein(CRP) on effects of platelets concentrates(PC) transfusion for bleeding patients with thrombocytopenia.Methods To investigate peripheral blood platelets count,clinical bleeding before(CRP test simultaneously) and 12～16 hours after PC transfusion for 45 non-fever,non-splenomegaly and non-DIC(disseminated intravascular coagulation,DIC) patients with leukemia,aplastic anemia,or solid tumor chemotherapy,which had bleeding and needed PC transfusion.All cases were divided into two groups:CRP normal and CRP higher one according to their CRP results.Each group were also classified as non-dexamethasone and dexamethasone division(10mg dexamethasone intravenous injection before transfusions) respectively,in order to analyze the relationships between effects of PC transfusion and serum levels of CRP or dexamethasone.Results The peripheral blood platelets counts (33.2?9.2)?109/L after PC transfusions in CRP normal group were more than that (25.4?10.4)?109/L,in CRP higher group,with significant differences(t=4.42,P
