Effect of sodium-calcium exchanger and its inhibitors on arrhythmia
- VernacularTitle:钠钙交换体及其抑制剂在心律失常中的作用
- Author:
Lei SHEN
;
Yulin WU
- Publication Type:Journal Article
- Keywords:
sodium-calcium exchanger;
reverse mode;
calcium overload;
sodium-calcium exchanger inhibitor;
arrhythmia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In cardiomyocytes,sodium-calcium exchanger(NCX) is regarded to play an important role in the regulation of intracellular Ca~(2+) concentration.During the cardiac ischemia/reperfusion or cardenolide intoxication,the inflow Ca~(2+) through NCX reverse mode induce calcium overload and arrhythmia.Recently,the benzyloxyphenyl derivatives have been developed as selective NCX inhibitors,which may have therapeutic potential as a new remedy for arrhythmias.
