Research progress on endothelial nitric oxide synthase uncoupling
- VernacularTitle:内皮型一氧化氮合酶脱偶联的研究进展
- Author:
Jianpu ZHENG
;
Ka BIAN
- Publication Type:Journal Article
- Keywords:
eNOS uncoupling;
endothelial dysfunction;
nitric oxide;
oxidative stress;
tetrahydrobiopterin
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial dysfunction in various vascular diseases is associated with reduced nitric oxide(NO) bioavailability.It has been clearly demonstrated that endothelial nitric oxide synthase(eNOS) uncoupling plays a key role in above vascular pathological status.eNOS uncoupling is characterized by eNOS generating super oxide rather than NO which may resulted from the increased oxidative stress,lack of eNOS protein cofactor tetrahydrobiopterin(BH4),or supplement shortage of eNOS substrate L-arginine.Accumulating evidences suggest that reversal of eNOS uncoupling by ether reduction of oxidative stress or promotion the bioavailability of BH4 and L-arginine may serve as a novel therapeutic strategy for endothelial dysfunction and cardiovascular diseases,such as hypertension,diabetes,and atherosclerosis.
