Effects of novel compound C333H on glucose and lipid metabolism
- VernacularTitle:新化合物C333H降脂降糖作用的研究
- Author:
Cheng XU
;
Lili WANG
;
Yinglin CAO
;
Song LI
- Publication Type:Journal Article
- Keywords:
C333H;
lipid metabolism;
type 2 diabetes;
PPAR
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of the novel compound C333H on reduce blood glucose and lipid in vivo.Methods Normal KM mice,hyperlipidaemia mice and type 2 diabetic mice by intragastric gavage were used and total RNA from liver,adipose and skeletal muscle were isolated for RT-PCR.Results C333H reduced blood lipid level and improved glucose metabolism.In addition,C333H increased expressions of LPL,aP2 and GluT4 at transcriptional level.Conclusion C333H is a novel PPAR?/? agonist,signivicantly reducing blood lipid and glucose,which had potential as a therapy for type 2 diabetes.
