Effects of Alendronate sodium on osteogenic and adipogenic differentiation of bone marrow stromal cells
- VernacularTitle:阿伦磷酸钠对小鼠骨髓基质细胞成骨和成脂分化的影响
- Author:
Xianghui LI
- Publication Type:Journal Article
- Keywords:
alendronate sodium;
bone marrow stromal cells;
osteogenic differentiation;
adipogenic differentiation
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of alendronate sodium on osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells(MSCs).Methods The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT),alkaline phosphatase(ALP) activity assay and Oil Red assay were used to investigate the effects of alendronate sodium on the growth,ostogenesis and adipogenesis of MSCs,respectively.Results Alendronate sodium promoted the proliferation of primary mouse bone marrow stromal cells,inhibited osteogenic differentiation and adipogenic differentiation of MSCs at concentrations of 1?10~(-10),1?10~(-9),1?10~(-8),1?10~(-7),1?10~(-6) and 1?10~(-5) mol.L~(-1),respectively(P
