Effect of combination of extracts of ginseng and ginkgo biloba on neurotransmitters in whole brain of ?-amyloid peptide_(1-40)treated rat
- VernacularTitle:人参、银杏叶提取物对?-淀粉样蛋白_(1-40)毒性损伤大鼠全脑神经递质的影响
- Author:
Weihong CONG
;
Jianxun LIU
;
Li XU
- Publication Type:Journal Article
- Keywords:
ginseng;
ginkgo biloba;
extract;
?-amyloid peptide;
acetylcholine;
monoamines
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To detect the effect of a combination of extracts of ginseng and ginkgo biloba(Naoweikang,NWK) on acetylcholine,monoamines and their metabolites in ?-amyloid peptide(A?)_(1-40) treated rats and the potential mechanisms.Methods A 1-month NWK(15.5,31 and 62 mg?kg~(-1),respectively) administration to rats was performed daily after bilateral injection of A?_(1-40)(4 g?L~(-1) for each side) into hippocampus.Acetylcholine(ACh) was determined with an improved HPLC-ECD method,which is combined with two immobilized enzyme reactors.Monoamines and their metabolites were also determined with HPLC-ECD.Result Compared with shams,ACh and serotonin(5-HT) in whole brains in models decreased significantly(P
