Restraint stress down-regulates L-Arg/NOS/NO pathway of platelet and aortic intima in rats
- VernacularTitle:束缚应激大鼠血小板及血管内膜的L-精氨酸/一氧化氮合酶/一氧化氮通路下调
- Author:
Yuying CUI
;
Chaoshu TANG
;
Bin GENG
- Publication Type:Journal Article
- Keywords:
Seress;
Tunica intima;
Blood platelets;
Nitric oxide;
Nitric-oxide synthase;
Arginine
- From:
Journal of Peking University(Health Sciences)
2004;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate alteration and cross link of the aortic intima and platelet endogenous L-Arg/NOS/NO pathway induced by water immersion restraint (WIR) stress. Methods: After 7 h of WIR stress, the aortic intima was isolated and prepared the platelet, then NO_2- production released from aortic intima and platelet was measured with Greiss regent, NOS activity and L-arginine transport activity were detected by isotope tracer method. Results: After 7 h of WIR stress, the levels of NO_2- from platelet and aortic intima obviously decreased by 57% and 46% respectively as comparied with the control rats (P
