Primary establishment of HAPE animal model
- VernacularTitle:高原肺水肿动物模型的初步研究
- Author:
You CHEN
- Publication Type:Journal Article
- Keywords:
high altitude pulmonary edema;
hypoxia;
cold;
exercise;
SD rat;
animal model
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To set up an animal model of high altitude pulmonary edema(HAPE) by putting SD rats in the condition simulating high altitude where is hypoxic and cold,in addition the SD rats are forced to swim.Methods SD rats were divided into normal control group and experiment group(SD rats were put into the stimulated 4 000-meter low pressure chamber;Temperature: 8:00-20:00 10 ℃,20:00-8:00 4 ℃;Everyday the rats were forced to swim 6 times a day,once every 4 hours,each for 40 min).The rat lung arterial pressure was observed and pulmonary tissue was collected for pathological examination at 24,48,72 h.Results PaO_(2),SaO_(2),_()PaCO_(2) in the experiment decreased significantly.Lung arterial pressure increased significantly at 72 h,consistent with the progression of clinical HAPE.About 70.2% rats in the experiment exhibited swollen and thicken pulmonary tissue,the smaller alveolar cavity,but no case of alveolar edema was found.Conclusion The animal model of HAPE is successfully replicated,but the alveolar model of HAPE needs further study.
