Decreased expression of apelin in lung and heart tissue of rats induced by hypoxia
- VernacularTitle:缺氧致大鼠心肺组织中apelin的表达降低
- Author:
Yongsheng GONG
- Publication Type:Journal Article
- Keywords:
apelin;
hypoxia;
hypertension,pulmonary;
rat
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the probable function of new peptide apelin in pathological proceeding of pulmonary hypertension induced by hypoxia.Methods Twenty male Sprague-Dawley rats were randomly divided into normal control group and hypoxia group(9%-11% O_(2),9 h/d,6 d).The mean of pulmonary arterial pressure(mPAP),mean carotid arterial pressure(mCAP) and the weight ratio of right ventricle to left ventricle plus septum(RV/LV+S) were measured.The concentration of apelin in the plasma,right ventricular myocardium and lung tissue were measured by radioimmunity.The expression of apelin gene in right ventricular myocardium and lung tissue were measured by reverse transcription-polymerase chain raction(RT-PCR).Results The mPAP and RV/(LV+S) of hypoxic group were respectively more by 26.06% and 10.83% than control group(P
