The meta-analysis of Laurance-Moon-Bardet-Biedl syndrome.
- VernacularTitle:多指(趾)-肥胖-肾-眼综合征2例并文献复习分析
- Author:
Yihua YANG
;
Weifeng NI
;
Shenren CHEN
- Publication Type:Journal Article
- Keywords:
Laurance-Moon-Bardet-Biedl syndrome;
Meta-analysis;
Diagnosis
- From:
Chinese Journal of Practical Internal Medicine
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To deepen the clinicians' impression on the Laurance-Moon-Bardet-Biedl syndrome(LMBBS),we made a summary in the incidence and clinical manifestations of the disease in China comparing with foreigners.Methods We made evidence-based meta-analysis about the 2 cases reports in 1987 and 2003 in our hospital and literature review of 462 cases in foreign countries and 94 cases in China.Results LMBBS patients,with more frequency of consanguinity and family history,retinal dystrophy,mental retardation,obesity,polydactyly,hypogenitalism,often had many complicated and variable clinical manifestations.Conclusion To avoid intrafamiliy marriage would reduce the incidence rate.The diagnostic criteria and ascertainment methods introduced recently do benefit the early diagnosis in their childhood period.
