The significance of Inhibition of NF-?B by I?B? in Cerebral Ischemia
- VernacularTitle:I?B?对NF-?B的抑制作用在脑缺血中的意义
- Author:
Lijie CHEN
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
nuclear factor-?B;
cerebral ischemia;
apoptosis;
neuron
- From:
International Journal of Cerebrovascular Diseases
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-?B (NF-?B) is a nuclear transcription factor that regulates the expressions of multiple genes. It can be activated during cerebral ischemia; it is closely correlated with the inflammatory reaction and apoptosis during cerebral ischemia. NF-?B inhibitor ? (I?B?), an important inhibitor factor of NF-?B, can regulate the survival and death of neuron in the ischemia penumbra. Therefore, the inhibition of the degradation of I?B? and the prevention of the activation of NF-?B with drugs or molecular biological methods has become an important approach in study of the effect of NF-?B at present. Recent studies have indicated that I?B? itself may also participate in the regulation of apoptosis.
