Morphological study of preventive effect of total saponin from Tribulus terrestris on injury to cardiomyocyte after hypoxia-reoxygenation
- VernacularTitle:蒺藜总皂苷对缺氧复氧心肌细胞存活及损伤形态的影响
- Author:
Xiangang WANG
;
Huijun YIN
;
Dazhuo SHI
- Publication Type:Journal Article
- Keywords:
myocardium;
gross saponins from Tribulus terrestris;
myocardial reperfusion injury
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effects of total saponin from Tribulus terrestris (GSTT) on cardiomyocytes subjected to low oxygen tension and re-oxygenation injury in vitro. Methods First passage of cultured cardiomyocytes was subjected to hypoxia followed by oxygenatim. The cells were divided into 4 groups, namely normal group, injury group, and large and low dose of GSTT groups. The frequency of contraction, survival rate and release of myocardial enzymes were determined. The morphologic changes were observed with light and electron microscopy. Results Both large and low dose of GSTT significantly improved the survival rate of cardiomyocytes after hypoxia and re-oxygenation injury (P
