Effects of gross saponin from Tribulus terrestris on acute myocardial ischemia/reperfusion injury in rats
- VernacularTitle:蒺藜总皂苷对大鼠急性心肌缺血再灌注损伤的影响
- Author:
Xiangang WANG
;
Huijun YIN
;
Dazhuo SHI
- Publication Type:Journal Article
- Keywords:
gross saponins from Tribulus terrestris, myocardial reperfusion injury;
myocardial infarction
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of gross saponin from Tribulus terrestris (GSTT) on myocardial ischemia/reperfusion (MI/R) injury. Methods A model of myocardial MI/R injury of the myocardium was reproduced by ligation of left descending artery for 45min followed by releasing the ligation for 2 hours in rats. 64 SD rats were divided randomly to 4 groups, i.e. sham-operated group, model group, large and low dose of GSTT groups. HE staining was examined to assess myocardial pathological changes. TTC staining was used to determine myocardial infarction area. Serum contents of lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and malondialdehyde (MDA) were also determined. Results Both large and low dose of GSTT improved myocardial pathological changes after ischemia/reperfusion. Large dose of GSTT reduced myocardial infarction area (P
