Influence of propofol on the expression of iNOS after spinal cord injury in rat
- VernacularTitle:异丙酚对大鼠脊髓损伤后诱导型一氧化氮合酶表达的影响
- Author:
Yu SHANG
;
Ying ZI
;
Yajin ZHANG
- Publication Type:Journal Article
- Keywords:
spinal cord injuries;
propofol;
nitric-oxide synthase
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of propofol on the induction of inducible nitric oxide synthase (iNOS) expression in spinal cord after spinal cord injury (SCI) in rats. Methods SCI model was reproduced according to Allen′s method with modification. Seventy-four SD rats were randomly divided into three groups: normal group (n=4), SCI with propofol treatment group (n=35), and SCI with saline treatment group (n=35). Immunohistochemistry and Western blot were employed to detect iNOS expression in spinal cord at different time (1h, 3h, 8h, 1d, 3d, 7d, 14d). Results The results showed that iNOS expression in spinal cord of propofol treatment group was significantly decreased compared with that of saline treatment group (P
