The role of VEGF on the growth of hypertensional saccular aneurysm and its mechanism: an experimental study
- VernacularTitle:高血压促囊性动脉瘤增大过程中VEGF的作用及其机制的实验研究
- Author:
Zhenghui SUN
;
Bainan XU
;
Dingbiao ZHOU
- Publication Type:Journal Article
- Keywords:
hypertension;
aneurysm;
carotid artery, external;
vascular endothelial growth factors
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of VEGF on the growth of hypertensional saccular aneurysm and its mechanism. Methods Twenty-four SD rats were divided into 2 groups randomly (A and B, each with 12 rats). Saccular aneurysms of the carotid artery were reproduced by treatment of initial segment of the external carotid artery (1mm long) with elastase. In group A, the posterior branches of both renal arteries were ligated in order to produce marked elevation of blood pressure. In Group B hypertension was not produced to serve as the control group. After 8 weeks, the blood pressure and the size of the aneurysms were measured. Then formalin was infused into the arteries for fixation, and aneurysms were resected. The expression of vascular endothelial growth factors (VEGF) in aneurysmal wall was assessed with immunohistochemical analysis. Results The size of aneurysms: after 8W, significant difference was found between A and B group (P
