Effects of tetramethyl pyrazine (TMP) on noise induced hearing loss in hypobaric environment
- VernacularTitle:川芎嗪对低气压噪声环境条件下豚鼠听阈改变的影响
- Author:
Yue FENG
;
Liang ZONG
;
Hua HUANG
- Publication Type:Journal Article
- Keywords:
tetramethyl pyrazine;
low pressure hypoxia;
evoked potentials, auditory, brain stem;
hearing loss, noise-induced
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of tetramethyl pyrazine(TMP)on noise induced hearing loss (NIHL) in hypobaric environment. Methods Normal guinea pigs were randomly divided into two groups, in which the animals were exposed to noise for 1 day or 7 days, respectively. Each group was randomly divided into 3 subgroups: control, TMP-treatment and TMP-pretreatment groups. All animals were exposed to 110dB white noise in hypobaric chamber to repreduce a low pressure environment of 5500m altitude. The mechanism underlying TMP protection was studied by detecting the auditory brainstem response (ABR). Results ABR threshold shift in different degrees occurred in every group, especially in animals exposed to 4kHz. The threshold shifts increased in extent along with prolongation of exposure time. The longer they were exposed, the more ABR threshold shifts. ABR threshold shifts occurred more severely in control group compared with the two TMP-utilized groups. Conclusion TMP has certain protective effect on NIHL in a hypobaric environment.
