Analysis of prevention and treatment of cyclosporine-A's hepatotoxicity in patients with renal transplantation
- VernacularTitle:肾移植术后环孢素A肝毒性防治回顾性分析
- Author:
Ke WANG
;
Bingyi SHI
;
Yeyong QIAN
- Publication Type:Journal Article
- Keywords:
renal transplantation;
cyclosporine-A;
tacrolimus;
hepatotoxicity
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the hepatotoxicity of cyclosporine-A, tacrolimus and other immunosuppressive drugs in patients with renal transplantation. Methods In 346 cases undergone renal transplantation, ALT, AST, BILT and BILD levels of venous blood 1-90 days after operation, and treatment methods and outcome were reviewed, in order to evaluate the effectiveness of the treatment of hepatotoxicity. Results In CsA group, the occurrence rate of liver dysfunction was 26.9%, in whom ALT, AST and BILD increased apparently (P0.05). In MMF and MRZ group, the incidence of liver dysfunction was almost the same. In 18 cases the drug was changed into FK506, ALT, AST, BILT and BILD all apparently decreased 1 week later (P
