Preliminary study on computer automatic quantification of brain atrophy
- VernacularTitle:计算机自动定量诊断脑萎缩的初步研究
- Author:
Chuanfu LI
;
Kangyuan ZHOU
- Publication Type:Journal Article
- Keywords:
Brain diseases;
Anthropometry;
Tomography, X-ray computed;
Image processing,computer-assised
- From:
Chinese Journal of Radiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variability of normal brain volume with the sex and age, and put forward an objective standard for computer automatic quantification of brain atrophy. Methods The cranial volume, brain volume and brain parenchymal fraction (BPF) of 487 cases of brain atrophy (310 males,177 females) and 1901 cases of normal subjects (993 males, 908 females) were calculated with the newly developed algorithm of automatic quantification for brain atrophy. With the technique of polynominal curve fitting, the mathematical relationship of BPF with age in mormal subjects was analyzed.Results The cranial volume, brain volume and BPF of normal subjects were (1 271 322?128 699) mm3, (1 211 725?122 077) mm3 and (95.3471?2.3453)% , respectively, and those of atrophy subjects were (1 276 900?125 180) mm3,(1 203 400?117 760) mm3 and BPF (91.8115?2.3035)% respectively. The difference of BPF between the two groups was extremely significant (P0.05). The expression P(x)=-0.0008x2+0.0193x+96.9999 could accurately describe the mathematical relationship between BPF and age in normal subject (lower limit of 95% CI y=-0.0008x2+0.0184x+95.1090). Conclusion The lower limit of 95% confidence inter mathematical relationship between BPF and age could be used as an objective criteria for automatic quantification of brain atrophy with computer.
