Experimental Research on Xingnaojing Injection to Oxide Injury of Cerebral Ischemia Reperfusion
- VernacularTitle:醒脑静注射液对脑缺血再灌注氧化损伤的实验研究
- Author:
Hongbo ZHANG
;
Jianfeng DAI
;
Binhui ZHANG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
reperfusion;
free radical;
Xingnaojing Injection
- From:
Journal of Zhejiang Chinese Medical University
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Experiment the effective method to improve cell injury of cerebral ischemia.MethodMake Mongolirn-Gerbil acute full cerebral ischemia model with ligation of double main carotid arteries,observe the influence of intervening abdomen injection of western medicine Nimodipin and TCM Xingnaojing on MDA and SOD in cerebral tissue of Mongolirn-Gerbil in acute period of ischemia reperfusion.ResultIt finds that Nimodipin and Xingnaojing both can markedly increase SOD activity and decrease MDA content,there’s no obvious difference between them,while there’s difference among different dosages of Xingnaojing,the effect is rising with dosage increased.ConclusionAs a Chinese drug of anti-free radical injury,Xingnaojing has similiar effect with Nimodipin.
