Human lung-derived mesenchymal stem cells inhibit T lymphocyte proliferation
- VernacularTitle:人肺来源的间充质干细胞对T淋巴细胞增殖的影响
- Author:
Mingzhang XIANG
;
Yaoguang JIANG
;
Huichun WANG
;
Yidan LIN
- Publication Type:Journal Article
- Keywords:
lung;
mesenchymal stem cell;
immunomodulation
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunoregulatory ability of human lung-derived mesenchymal stem cells (MSCs) on T cells. Methods MSCs were isolated and cultured from human fetal lung. The immune phenotype was tested by flow cytometry and T lymphocyte proliferation assessed by thymidine incorporation. Results HLA-DR, CD86, and CD80 were not expressed in human lung-derived mesenchymal stem cells. The proliferation of peripherial blood-derived T cells was suppressed and this suppression seemed dependent on the concentration of MSCs. Conclusion Human lung-derived MSCs have been proved to possess immunomodulatory ability.
