Gene Expression Profile of Ischemia Boundary Zone of Rat Acute Myocardial Infarction.
- VernacularTitle:大鼠心肌梗死急性期缺血交界区基因表达谱特征
- Author:
Huiliang ZHANG
;
Rongli ZHANG
;
Guoan LUO
- Publication Type:Journal Article
- Keywords:
Acute Myocardial infarction;
Gene expression profile;
Gene chip
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the molecular mechanism of acute myocardial infarction(AMI),searching for protective genes and injury-related ones,aimed to fight myocardial infarction disease.Methods Rat model of AMI was established with left anterior descending (LAD) coronary artery ligation.Gene chip was used to verify the mechanism of AMI at molecular level.Results The author screened out 190 differential expression genes between AMI rat myocardium and sham operated rat myocardium in the gene expression profile study;In the Model/Sham operation gene expression profile,there were 89 genes depressed expression and 101 genes elevated expression.Most of them involve in the 12 known categories,and relate to the metoblolism,signal and trandport pathways.Conclusion The major possible mechanism of AMI is to regulate the local expression of related gene through a multi-pathway.
