Effect of Early Postoperative Enteral Immunonutrition in Patients with Gastric Cancer.
- VernacularTitle:胃癌术后不同营养途径对病人愈后的影响
- Author:
Bing WEN
- Publication Type:Journal Article
- Keywords:
Enteral nutrition;
Immune;
Inflammatory response;
Arginine;
Glutamine;
Omega-3 fatty acids
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of early postoperative enteral immunonutrition on host nutritional status,immune and inflammatory responses.Methods Ninety six patients with gastric cancer were randomized to receive either an immune enhancing enteral diet or an isocaloric,isonitrogenous control diet for 7 days.Enteral feeding was initiated 24 hours after surgery.Host immunity was evaluated by IgG、IgM、IgA、CD4、CD8、CD4/CD8,and inflammatory response was reflected by IL-1?、IL-2、IL-6、IL-10、TNF-?.Total protein,albumin,prealbumin,transferring and nitrogen balance were determined as nutritional indicators.Results After the study,prealbumin,IgA,CD4,and CD4/CD8 levels were significantly higher in study group than in control group.IL-6,TNF-?concentrations were significantly lower in study group than in control group.Conclusions Postoperative administration of immunonutrtion in patients with gastric cancer can positively modulate postoperative immunosuppressive and inflammatory responses.
