Effect of high dose folic acid combined with Vitamin B_(12) to homocysteine plasma level in maintenance hemodialysis patients
- VernacularTitle:叶酸联合维生素B_(12)对血透患者同型半胱氨酸水平的影响
- Author:
Jinqun WU
;
Zhixian PAN
;
Yuping CHEN
;
Han ZHONG
- Publication Type:Journal Article
- Keywords:
Cysteine;
Folic acid;
Vitamin B_(12);
Renal dialysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigagte the effect of high dose folic acid(FA) combined with vitamin B_(12) to homocysteine plasma level in maintenance hemodialysis(MHD) patients.Methods 52 MHD patients were randomly divided into 4 groups,receiving of FA 0,15,30,60mg/d orally for 3 months and those who receiced folic acid were given vitamin B_(12) 500?g/d,im.The levels of plasma FA,vitamin B_(12) and total homocysteine(tHcy) at 0,1,2,3,6 month were detemined by radioimmunoassay and flurescence polarization immunoassay respectively.Results Levels of tHcy in MHD patients were significantly higher than those in healthy controls.Both high dose and low dose FA could lower tHcy plasma concentrations,but had no significant difference in homocysteine reduction ratio,and could not normalize it.Three doses of FA combined with vitamin B_(12) treatment could effectively increase the plasma FA and vitamin B_(12) concentrations.Conclusion tHcy is elevated in the majority of MHD patients.Low dose of FA combined with vitamin B_(12) can decrease tHcy plasma levels,but cannot normalize it.
