Clinical Effects of Benoxal (Benzoyl peroxide) on Acne Vulgaris.
- Author:
Tae Joong NAM
;
Kee Chan MOON
;
Jong Min KIM
;
Won Suk KIM
;
Yoo Shin LEE
- Publication Type:Original Article
- MeSH:
Acne Vulgaris*;
Benzoyl Peroxide;
Burns;
Dermatitis, Contact;
Dermatology;
Female;
Humans;
Propionibacterium acnes;
Pruritus;
Sensation;
Seoul;
Thiram
- From:Korean Journal of Dermatology
1978;16(6):459-463
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Benzoyl peroxide has been known to have bacteriostatic activity against Corynebacterium acnes and to have comedolytic action in patients with acne vulgaris. The present study was undertaken to evaluate the therapeutic effect of Renoxal, a 5% benzoyl peroxide lotion, in patients with acne vulgaris. A total of 35 patients entered this study at the Department of Dermatology, Seoul National University Hospital during the five months period from March to July, 1978. All patients were instructed to apply Benoxal on their affected sites once or twice daily; and the number of lesions on three fixed areas were counted before and every week for four weeks after the treatrnent. Two female patients stopped the application due to developrnent of contact dermatitis to Benoxal The results observed in the 33 patients were as follows: 1. The percentage decrease in total number of lesions in four weeks after treatment was 51.1% 2. Closed and open comedones were gradually eliminated; and their numbers were decreased in four weeks after treatment by 45. 8% and 55. 3% respectively. The papules were decreased. by 59. 1 @2 after the first week of treatment, but showed. a transient lag around tbe second week and then marked 61. 5% in four weeks after treatment. 3. Observed side effects included burning sensation,(3 cases), tightness (3 cases), itching sensation (2 cases) and scaling (1 case). All were tolerable without any specific measure or discontinuance of the application. The authors concluded througb this experiment that Benoxal (5% benzoyl peroxide lotion) is a very effective local therapeutic agent in the treatment of acne vulgaris patients.
