Effect of liquorice on airway inflammation and TH_1/TH_2 imbalance in mouse model
- VernacularTitle:甘草对慢性小鼠哮喘模型气道炎症及外周血Th_1/Th_2失衡的影响
- Author:
Xiaohua LV
;
Tie WU
;
Hui WANG
;
Dongyun QIN
- Publication Type:Journal Article
- Keywords:
liquorice;
bronchial asthma;
mice model;
Th_1/Th_2 imbalance
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of liquorice on airway inflammation and Th_1/Th_2 imbalance in chronic asthma. METHODS: The chronic asthma model was established by intraperitoneal ovalbumin. The effect of liquorice on mice model of chronic bronchial asthma was observed, and the levels of serum IFN-? and IL-4 were tested by ELISA. RESULTS: Decreasing inflammatary cells infiltration in pulmonary tissue slices of tiny bronchial wall together with increasing serum IFN-? and decreasing serum IL-4 levels. CONCLUSION: Liquorice can adjust Th_1/Th_2 imbalance and inhibit the airway inflammation.
