Therapeutic effect of oat ?-glucans on serum lipid levels of rats with experimental hyperlipemia
- VernacularTitle:燕麦?-葡聚糖治疗大鼠高脂血症
- Author:
Suping PEI
- Publication Type:Journal Article
- Keywords:
oat ?-glucans;
chitosan oligosaccharide;
hyperlipemia
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic effect of oat ?-glucans on serum lipid levels of rats with experimental hyperlipemia.Methods: Rats were fed on high fat forage for 3 weeks to establish hyperlipemia models,then the model rats were orally given oat ?-glucans at doses of 133,266 and 533 mg/(kg?d) separately.At the same time,there were 3 control groups including chitosan ligosaccharide[200 mg/(kg?d)],normal,and high blood lipid(model rats fed with distilled water).Serum levels of total cholesterol(TC),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were assayed in rats of all groups and the results were compared.Results: ?-glucans obviously decreased the levels of TC and LDL-C and increased HDL-C in rat hyperlipemia models.The reduction of serum lipid level in 4-week ?-glucans treatment rats was more obvious than that in 3-week ?-glucans treatment rats.Besides,?-glucans showed an obvious dosage dependent effect in reducing serum lipid level without adverse effect.Oat ?-glucans had a better lipid-reducing effect than ligosaccharide did.Conclusion: Oat ?-glucans can obviously decrease serum lipid in rats with hyperlipemia.
