Glucagon-like peptide-1: a new Alzheimers disease interventive strategy
- VernacularTitle:胰高血糖素样肽-1——阿尔采末病治疗新策略
- Author:
Mei GAO
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1;
neurodegeneration;
Alzheimers disease
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon-like peptide-1 is an endogenous 30-amino acid gut peptide,which binds at the GLP-1 receptor coupled to the cyclic AMP second messenger pathway.Stimulation of neuronal GLP-1 receptors plays an important role in regulating neuronal plasticity and cell survival.GLP-1 has been documented to induce neurite outgrowth and to protect against excitotoxic cell death and oxidative injury in cultured neuronal cells.Moreover,GLP-1 and Exendin-4,a naturally occuring more stable analogue of GLP-1 that likewise binds at the GLP-1 receptor,were shown to reduce levels of ?-amyloid precusor protein(?APP) in neurons.Treatment with GLP-1 or a related peptide beneficially affects a number of the therapeutic targets associated with Alzheimers disease(AD).This review will consider the potential therapeutic relevance of GLP-1 to AD.
