Research on the effect of corticotropin-releasing hormone receptors in stress reaction
- VernacularTitle:促肾上腺皮质激素释放激素受体在应激反应中的作用研究
- Author:
Chun ZENG
;
Can YAN
;
Zhiwei XU
;
Lili WU
- Publication Type:Journal Article
- Keywords:
corticotropin-releasing hormone;
receptor;
stress
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Corticotropin-releasing hormone(CRH) is the key regulator during stress reaction which integrates endocrine,autonomic,immune and behavioral responses to stressors.Receptors mediating the action of CRH have been identified as CRH-R1,CRH-R2 and CRH-R3.In the process of stress reaction,CRH mainly interacts with CRH-R1 and CRH-R2,producing multiple physiological and pathological effects.In recent years,by employing transgenic animals,selective CRH-receptor antagonists and special CRH-receptor agonists,the effect of CRH receptors on stress reaction and its mechainisms have been deeply realized.
