A new immune strategy:Transcutaneous immune
- VernacularTitle:免疫新策略:经皮免疫
- Author:
Jing WANG
;
Jinhong HU
;
Quangang ZHU
;
Cheng PENG
- Publication Type:Journal Article
- Keywords:
transcutaneous immune(TCI);
skin immune system;
Langerhans′cells(LC);
vaccine;
transdermal drug delivery system(TDDS);
adjuvant
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Transcutaneous immunization(TCI),the topical application of antigen and adjuvant directly onto intact skin,which can safely and effectively elicit systemic and celluar immune responses in mice and humans against a variety of antigens,is a novel method of vaccine delivery.Not only the skin has evolved as a barrier to prevent external agents,including pathogens,from entering the body,but also it has a complex and efficient immune system,which includes Langerhans′ cells and dendritic cells.The skin is an attractive target for vaccine delivery.By targeting the body′s natural defense system,TCI attempts to produce an efficient immune response.All these results highlight the likelihood that TCI will play an important role in vaccine applications in the future.
