The function,regulation and development of heme oxygenase-1 in the liver disease
- VernacularTitle:血红素氧化酶功能和调节及其在肝病发生中的研究进展
- Author:
Xiaohong WANG
- Publication Type:Journal Article
- Keywords:
Heme oxygenase,anti-oxidant,the signal transduction,promoter
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Heme oxygenase(HO) is the rate-limiting enzyme in the degradation of heme.Three HO isoforms have been identified:HO-1,HO-2 and HO-3.The substances of heme degradation,carbon monoxide(CO),biliverdin and free iron(Fe~(2+)),have an important function in anti-oxidant and protecting cells.And the anti-oxidant function of induction HO-1 expression is mediated in the signal transduction of HO-1 gene expression and the promoter of HO-1 gene in the cells.So the new way is provided in the relevent liver-injury which is caused in anti-oxidant stress or non-oxidant stress.
