Protective effects of hydroxysafflor yellow A on acute myocardial ischemia in dogs
- VernacularTitle:羟基红花黄色素A对犬急性心肌缺血的保护作用
- Author:
Xinzhi LI
;
Jianxun LIU
;
Xiaohong SHANG
;
Jianhua FU
- Publication Type:Journal Article
- Keywords:
hydroxysafflor yellow A;
myocardial ischemia;
myocardial blood flow;
oxygen metabolism;
endothelin;
epicardiogram
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the protective effects of hydroxysafflor yellow A(HSYA) on acute myocardial ischemia in dogs.Methods The acute ischemia models were prepared by ligation of left anterior descending(LAD) artery.The myocardial blood flow(MBF) was determined by ultrasonic doppler,the oxygen metabolism was recorded using blood-oxygen analysis,and the ET was measured with radioimmunological assay.The experiments adopted epicardiogram mapping to measure the scope and the degree of myocardial ischemia,and used quantitative histological assay to determine the size of myocardial infarction.Results HSYA was showed to obviously increase the MBF and the oxygen volume in coronary vein sinus.And the treatment could inhibit the ET release from the injured microvessels.Furthermore,HSYA could alleviate the degree of myocardial ischemia(?-ST),the scope of myocardial ischemia((N-ST),) and narrow the ischemic(area.) Conclusion HSYA was showed to inhibit the ET release,increase the MBF,improve the cardiac oxygen metabolism,and then inhibit the myocardial ischemia damage.
