The role of IL-8 and NF-?B in the airway inflammation of COPD in stable stage.
- VernacularTitle:IL-8和NF-?B在慢性阻塞性肺疾病缓解期气道炎症中的作用
- Author:
Jizhen WU
;
Yong QI
;
Lijun MA
- Publication Type:Journal Article
- Keywords:
COPD;
IL-8;
NF-Kb;
Induced sputum;
Airway inflammation
- From:
Chinese Journal of Practical Internal Medicine
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the role of IL-8 and NF-?B in the airway inflammation of COPD in stable stage.Methods From Mar.2003 to Sep.2005,select 26 COPD patients in stable stage,determine the concentration of IL-8 in the serum of induced sputum,separate the macropolycyte and determine the degree of active expression of NF-?B,the concentration of SOD,MDA and IL-8 in peripheral blood.Lung function(the percent of FEV_1/FEV_1 prospectived value,FEV_1/FVC)of all patients were investigated.Results The concentration of IL-8 in the serum of induced sputum of COPD patients was higher than the normal group obviously(P
